The Family Gene: A Mission to Turn My Deadly Inheritance


The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future When Joselin Linder was a teenager in the late 80s, her father grew ill His symptoms primarily, that his body was swelling and his lungs were filling with fluid leaking out of his lymphatic system confounded doctors, as they didn t seem to align with any known condition There seemed to be no discernible reason for this to be happening to an otherwise healthy, middle aged man And there seemed to be no way to treat his symptoms But some older relatives recognized the symptoms they were the sa When Joselin Linder was a teenager in the late 80s, her father grew ill His symptoms primarily, that his body was swelling and his lungs were filling with fluid leaking out of his lymphatic system confounded doctors, as they didn t seem to align with any known condition There seemed to be no discernible reason for this to be happening to an otherwise healthy, middle aged man And there seemed to be no way to treat his symptoms But some older relatives recognized the symptoms they were the same ones that had killed both his grandmother and his uncle in the mid 20th century Eventually the Linder family and their doctors began to realize that the condition was tied to genetics something was wrong with a gene that was being passed through this family and it was causing these symptoms As far as anyone could tell, just fourteen people in the entire world had this gene all descended from Joselin s great great grandmother and five had succumbed to the deadly disease that it caused By the time that Joselin s father succumbed to his illness in 1996, the medical community s understanding of genetic disorders was growing by leaps and bounds, but there were still huge gaps in the knowledge As the Human Genome Project neared completion and genetic mapping became a reality, medical experts studying the family began tracing the source of their disease They were looking for the exact chromosome that carried the faulty gene and trying to figure out exactly what it was doing to the body so that the fatal symptoms could be alleviated Meanwhile, Joselin and her sister Hillary were struggling to reconcile their desire to start a family with the fear that this faulty gene could be passed on to their own children This is a fascinating medical mystery that will appeal to anyone who s enjoyed books like The Immortal Life of Henrietta Lacks, which Linder herself namechecks in her explanation of genetic science Though some of the science gets a bit dense don t expect me to clearly explain exactly what this disease was doing to the vascular system and the liver, nor exactly how gene mapping works Linder does a pretty good job distilling it down into layman s terms After all, she s not a scientist and she s had to figure out what s going on inside her own body That being said, the writing could be a bit clunky at times I was reading an advanced copy, so it s possible thatediting was done, but I also think that this book came about from some work being done for a public radio piece that was eventually got scrapped And honestly, at times the sentence structure feltappropriate for a radio piece than for a book It s hard to explain, but the writing styles are understandably different between the the two mediums, and it doesn t always quite gel here Still, it s a book that will make you think Genetic diseases are absolutely terrifying Knowing that you are destined to develop a disease and there s nothing that can be done about it I can t even begin to imagine how difficult it must be to process that and carry on in spite of it The science of genetics is still relatively young and it suffers, to some extent, from public ignorance There are some people who question the ethics of genetic manipulation, but Linder argues that we need greater understanding of these diseases and their complicated roots She does an excellent job putting a human face and a human story on what could have easily become dry, clinical science talk A compelling medical mystery that involves a faulty gene that is inherited The author s legs began to swell when she was in her early 20 s and the medical profession was stumped as to the cause So began Joselin s journey to decipher what is truly going on She begins by reviewing her father s medical chart he was a physician as to what caused his death This is a true medical detective book that will leave readers cheering and hoping for Joselin and wondering about their relatives that died A compelling medical mystery that involves a faulty gene that is inherited The author s legs began to swell when she was in her early 20 s and the medical profession was stumped as to the cause So began Joselin s journey to decipher what is truly going on She begins by reviewing her father s medical chart he was a physician as to what caused his death This is a true medical detective book that will leave readers cheering and hoping for Joselin and wondering about their relatives that died peculiar deaths.I read an advance copy and was not compensated You should fight to live long and well, you should experience meaningfulness as often as you can, and the rest of the time you should just ignore death completely Joselin Linder, The Family GeneNon fiction memoir about a family with a genetic variant Joselin Linder inherited a unique gene from her father, which causes a currently unnamed disease that has resulted in the deaths of five family members In this memoir, the author documents her family s pain and suffering, the genetic research You should fight to live long and well, you should experience meaningfulness as often as you can, and the rest of the time you should just ignore death completely Joselin Linder, The Family GeneNon fiction memoir about a family with a genetic variant Joselin Linder inherited a unique gene from her father, which causes a currently unnamed disease that has resulted in the deaths of five family members In this memoir, the author documents her family s pain and suffering, the genetic research involved in tracing the source, and the medical analysis involved in discovering a treatment She talks about what it is like living with a potentially fatal condition This book covers a good amount of medical science in a manner easily understood by a layperson It shows how this family turns tragedy into an opportunity to work in partnership with doctors and scientists to understand and reduce the impact of this unique disease The author intersperses information about the history and recent advances in genetics into her personal story The writing style is colloquial, with humor sprinkled throughout, as a respite from the weighty topics Linder only touches the surface of the genetic engineering debate, instead offering her personal insight from a perspective of someone with a significant stake in the outcome Recommended to those interested in medically oriented memoirs, hereditary diseases, and genetic research I think fans of The Immortal Life of Henrietta Lacks, Brain on Fire, or Lab Girl may also appreciate it The Family Gene by Joselin Linder is everything I wish for in a medically oriented memoir Linder blends the science of genetics deftly with her own family s story It was so compelling that I flew through the book in just a day or so.When Joselin is just fifteen, she and her family begin to watch her father die a slow, painful and frankly horrific death He literally never received a diagnosis for this fatal disease The family begins to realize that his condition was very similar to two other The Family Gene by Joselin Linder is everything I wish for in a medically oriented memoir Linder blends the science of genetics deftly with her own family s story It was so compelling that I flew through the book in just a day or so.When Joselin is just fifteen, she and her family begin to watch her father die a slow, painful and frankly horrific death He literally never received a diagnosis for this fatal disease The family begins to realize that his condition was very similar to two other members of his family, now also deceased Then his brother dies Sounds overwhelmingly sad, doesn t it Full review at I was pulling into the parking lot of the supermarket where I shop, listening to NPR The interview with Ms Linder that was so fascinating, so interesting, I sat in the parking lot until the interview ended And I promptly ordered the book I have a potentially fatal genetic disorder, but at 72 I do not give it much thought I know of no one in my family history who had it But could it have been properly diagnosed Is my case a one off, a one time thing Am I the first documented case in my I was pulling into the parking lot of the supermarket where I shop, listening to NPR The interview with Ms Linder that was so fascinating, so interesting, I sat in the parking lot until the interview ended And I promptly ordered the book I have a potentially fatal genetic disorder, but at 72 I do not give it much thought I know of no one in my family history who had it But could it have been properly diagnosed Is my case a one off, a one time thing Am I the first documented case in my family Will any of my descendants develop it Ms Linder s account did not and cannot address mine, but it helped me understand I must say, Ms Linder has a wonderful gift for making complex scientific, medical, and genetic terms comprehensible to this lay personMy only reluctance to grant five stars is my disinterest in her personal Sturm und Drang during adolescence This review and others can be found on BW Book Reviews.This book took me a long time to listen to because it was interrupted by my finals No work means no listening to books Even though it was good, I couldn t listen to it on my free time thanks to being a responsible college student and doing this dreadful thing called studying Warn your kids about it It can get pretty terrifying.As I said, this was a good book It was fun and I really enjoyed how it was read Just very upbeat and light m This review and others can be found on BW Book Reviews.This book took me a long time to listen to because it was interrupted by my finals No work means no listening to books Even though it was good, I couldn t listen to it on my free time thanks to being a responsible college student and doing this dreadful thing called studying Warn your kids about it It can get pretty terrifying.As I said, this was a good book It was fun and I really enjoyed how it was read Just very upbeat and light most of the time When this book focuses on a family illness that is currently untreatable and has killed everyone who has it the author s father, uncle, and other people that s really impressive It s a very light book It s fun to read or listen to because it simply flows so well.Starting in the 90s, this book chronicles a family illness It begins with Joselin s father, a doctor who gets ill Very ill I think ill is an understatement to it Then, as he gets worse, then it comes out that other people in his family had the same symptoms that he does They also died of this mystery disease They don t know what it is, but know that everyone who has had it has a heart murmur, testing people in the family for it.At times, it was heavy with technical terms, but Joselin explained them perfectly I ve taken enough classes and read enough books to know most of the terms She just told it what it is in non doctor speak It s accessible to anyone, really All you have to know is the basics and anything beyond it, she explains Hell, even the basics get explained.It largely focuses on Joselin s experiences She s not a doctor, after all She s a woman who watched various members of her family get sick and die It s focused on her experience of this and the stages of grief that she went through While I m not sure I would have liked Joselin as a person for a good part of the story, I could appreciate it She reacted in a way people only can Still, hearing about her healing process didn t quite interest me as much as hearing the journey of discovery about their disorder.All in all, a good book that had very minor flaws for me FASCINATING I couldn t put this down An intriguingly sad mix of science, genetics, and family tragedies. A riveting medical mystery about a young woman s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicineWhen Joselin Linder was in her twenties her legs suddenly started to swell After years of misdiagnoses, doctors discovered a deadly blockage in her liver Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father who had died from a mysterious disease, ten years prior with that of an uncle who had died under similarly strange circumstances Delving further into the past, she discovered that her great grandmother had displayed symptoms similar to hers before her death Clearly, this was than a fluke Setting out to build a complete picture of the illness that haunted her family, Joselin approached Dr Christine Seidman, the head of a group of world class genetic researchers at Harvard Medical School, for help Dr Seidman had been working on her family s case for twenty years and had finally confirmed that fourteen of Joselin s relatives carried something called a private mutation meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation Here, Joselin tells the story of their gene the lives it claimed and the future of genomic medicine with the potential to save those that remain Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love [Reading] ➻ Peyton and the Paragon By Cathy Peper – 9facts.co.uk doctors discovered a deadly blockage in her liver Struggling to find an explanation for her unusual condition ➺ [Download] ➶ On Black Sisters Street By Chika Unigwe ➻ – 9facts.co.uk Joselin compared the medical chart of her father who had died from a mysterious disease ➶ [Reading] ➸ Remote Control (Nick Stone By Andy McNab ➫ – 9facts.co.uk ten years prior with that of an uncle who had died under similarly strange circumstances Delving further into the past [PDF / Epub] ☉ Superfrog and the Big Stink Author Michael Foreman – 9facts.co.uk she discovered that her great grandmother had displayed symptoms similar to hers before her death Clearly ➻ One Hand on the Claret Jug Free ➱ Author Norman Dabell – 9facts.co.uk this was than a fluke Setting out to build a complete picture of the illness that haunted her family [BOOKS] ✭ On the Road to Babadag ✯ Andrzej Stasiuk – 9facts.co.uk Joselin approached Dr Christine Seidman [Download] ➵ My Brothers Famous Bottom Gets Pinched Author Jeremy Strong – 9facts.co.uk the head of a group of world class genetic researchers at Harvard Medical School [Download] ➼ Assassins Heart (Assassins Heart, Author Sarah Ahiers – 9facts.co.uk for help Dr Seidman had been working on her family s case for twenty years and had finally confirmed that fourteen of Joselin s relatives carried something called a private mutation meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation Here ❰Reading❯ ➿ Earth Quest - Earth Medicine Author Kenneth Meadows – 9facts.co.uk Joselin tells the story of their gene the lives it claimed and the future of genomic medicine with the potential to save those that remain Digging into family records and medical history [Reading] ➸ Where Bear? Author Sophy Henn – 9facts.co.uk conducting interviews with relatives and friends ➶ [Read] ➲ Watch the Lady By Elizabeth Fremantle ➾ – 9facts.co.uk and reflecting on her own experiences with the Harvard doctor ❴Reading❵ ➸ Warrior Women Author Paula Guran – 9facts.co.uk Joselin pieces together the lineage of this deadly gene to write an exploration of family [Ebook] ➫ The Happy Puppy Handbook: Your Definitive Guide to Puppy Care and Early Training (English Edition) ➪ Pippa Mattinson – 9facts.co.uk history ❰KINDLE❯ ✿ Lifers Author Geoffrey Wansell – 9facts.co.uk and love I read this book quickly because I skimmed or skipped the essays about genetics, the movie reviews and the book reports There wasn t much left What there was of the author s story of her family s genetic mutation was interesting but inconclusive This was andeal that I bought for a buck or two These are always crapshoots I have realized two things from these books editors serve a vital function, andreviews are unreliable I did make it all the way through this one though ev I read this book quickly because I skimmed or skipped the essays about genetics, the movie reviews and the book reports There wasn t much left What there was of the author s story of her family s genetic mutation was interesting but inconclusive This was andeal that I bought for a buck or two These are always crapshoots I have realized two things from these books editors serve a vital function, andreviews are unreliable I did make it all the way through this one though even though I skipped long passages Definitely not a science book really not a science book would have benefitted from a science editor in fact but a book about living with a rare genetic disease from the person with that disease

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